SensUs 2025 Competition

SensTech is developing a continuous creatinine biosensor designed to monitor interstitial fluid (ISF) in real time for applications such as chronic kidney disease (CKD) management. The core sensing element is a Creatinine Specific Nanocomposite film synthesized via electropolymerization of pyrrole in the presence of creatinine. This process creates nanoscale binding sites specific to creatinine's shape and functional groups. The creatinine specific nanocomposite layer will be immobilized on a conductive electrode surface integrated into a microfluidic PDMS chamber designed as a narrow slit, maximizing the contact area with flowing ISF to ensure efficient analyte capture.

Our goal is to enable continuous, quantification of creatinine concentrations by transducing binding events into measurable electrochemical signals by using cyclic voltametry (CV). The system will provide real-time monitoring by detecting changes in the electrode's electricochemical properties as creatinine binds to the creatinine specific nanocomposite. By integrating this sensing platform into a compact, microfluidic form platform, we aim to develop a wearable, minimally invasive diagnostic device capable of long-term, point-of-care monitoring of renal function.