SensUs 2025 Competition

SensTech developed a continuous creatinine biosensor designed to monitor interstitial fluid (ISF) in real time for applications such as chronic kidney disease management. The core sensing element was a creatinine specific nanocomposite (CSN) film synthesized via electropolymerization of pyrrole in the presence of creatinine. This process created nanoscale binding sites specific to creatinine's shape and functional groups. The CSN layer was immobilized on a conductive electrode surface integrated into a microfluidic PDMS chamber designed as a narrow slit, maximizing the contact area with flowing ISF to ensure efficient analyte capture.

Our goal was to enable continuous quantification of creatinine concentrations by transducing binding events into measurable electrochemical signals using cyclic voltammetry. The system provided real-time monitoring by detecting changes in the electrode's electrochemical properties as creatinine bound to the CSN. By integrating this sensing platform into a compact, microfluidic form factor, we aimed to develop a wearable, minimally invasive diagnostic device capable of long-term, point-of-care monitoring of renal function.

Read more about our project in our SensUs 2025 Team Results Document (TRD).